Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis
Xiping Zhang, Hanqing Chen, Fang Liu et al.
Research Article — Peer-Reviewed Source
Original research published by Zhang et al. in Journal of Zhejiang University SCIENCE B. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.
Full text is available at the publisher.
Read at Publisher| DOI | 10.1631/jzus.b0820265 |
| Journal | Journal of Zhejiang University SCIENCE B |
| Year | 2009 |
| Authors | Xiping Zhang, Hanqing Chen, Fang Liu, Jie Zhang |
| License | Open Access — see publisher for license terms |
| Citations | 20 |