Glial Fibrillary Acidic Protein: Regulation by Hormones, Cytokines, and Growth Factors
Nicholas J. Laping, Bruce Teter, Nancy R. Nichols et al.
Research Article — Peer-Reviewed Source
Original research published by Laping et al. in Brain Pathology. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
Levels of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament protein, are altered during development and aging, GFAP also responds dynamically to neurodegenerative lesions. Changes in GFAP expression can occur at both transcriptional and translational levels. Modulators of GFAP expression include steroids, cytokines, and growth factors. GFAP expression also shows brain region-specific responses to sex steroids and of astrocyte-neuronal interactions. The 5'-upstream sequences of rat, mouse, and human are compared for the presence of response elements that are candidates for transcriptional regulation of GFAP. We propose that the regulation of the GFAP gene has evolved a system of controls that allow integrated responses to neuroendocrine and inflammatory modulators.
Full text is available at the publisher.
Read at Publisher| DOI | 10.1111/j.1750-3639.1994.tb00841.x |
| Journal | Brain Pathology |
| Year | 1994 |
| Authors | Nicholas J. Laping, Bruce Teter, Nancy R. Nichols, Irina Rozovsky, Caleb E. Finch |
| License | Open Access — see publisher for license terms |
| Citations | 231 |