Protecting the Aging Genome
Michael Petr, Tulika Tulika, Lina M. Carmona-Marin et al.
Research Article — Peer-Reviewed Source
Original research published by Petr et al. in Trends in Cell Biology. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of these pathways can lead to accelerated or premature aging and age-related decline in vital organs, supporting the hypothesis that maintaining a pristine genome is paramount for human health. Understanding how we cope with DNA damage could inform on the aging process and further on how deficient DNA maintenance manifests in age-related phenotypes. This knowledge may lead to the development of novel interventions promoting healthspan.
Full text is available at the publisher.
Read at Publisher| DOI | 10.1016/j.tcb.2019.12.001 |
| Journal | Trends in Cell Biology |
| Year | 2020 |
| Authors | Michael Petr, Tulika Tulika, Lina M. Carmona-Marin, Morten Scheibye‐Knudsen |
| License | Open Access — see publisher for license terms |
| Citations | 119 |