Suppression of tumor growth by novel peptides homing to tumor‐derived new blood vessels
Tomohiro Asai, Mayumi Nagatsuka, Koichi Kuromi et al.
Research Article — Peer-Reviewed Source
Original research published by Asai et al. in FEBS Letters. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
Novel peptides homing to angiogenic vessels were recently isolated from a phage-displayed random pentadecapeptide library. One of the isolated peptides, ASSSYPLIHWRPWAR, significantly suppressed the migration of VEGF-stimulated human umbilical vein endothelial cells. Dendoric ASSSYPLIHWRPWAR-peptide suppressed the formation of new blood vessels in dorsal air sac model mice. Furthermore, ASSSYPLIHWRPWAR-peptide and the fragment peptides containing WRP, which is revealed to be an epitope sequence, significantly suppressed the tumor growth, although 15-mer shuffled peptide derived from ASSSYPLIHWRPWAR and pentapeptides with alanine substitution of each residue of WRP did not. Taken together, ASSSYPLIHWRPWAR-peptide may cause tumor dormancy through inhibition of angiogenesis, and the WRP sequence may be the minimal and essential sequence for this activity.
Full text is available at the publisher.
Read at Publisher| DOI | 10.1016/s0014-5793(01)03265-3 |
| Journal | FEBS Letters |
| Year | 2001 |
| Authors | Tomohiro Asai, Mayumi Nagatsuka, Koichi Kuromi, Satoru Yamakawa, Kohta Kurohane, Kōichi Ogino, Michinori Tanaka, Takao Taki, Naoto Oku |
| License | Open Access — see publisher for license terms |
| Citations | 35 |