Circulation2004Open AccessHighly Cited

AMP-Activated Protein Kinase Inhibits Angiotensin II–Stimulated Vascular Smooth Muscle Cell Proliferation

Daisuke Nagata, Ryo Takeda, Masataka Sata et al.

196 citations2004Open Access — see publisher for license terms1 related compound

Research Article — Peer-Reviewed Source

Original research published by Nagata et al. in Circulation. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.

Abstract

Our findings indicate that Ang II-induced AMPK activation is synchronized with extracellular signal-regulated kinase signaling and that AMPK works as an inhibitor of the Ang II proliferative pathway. AMPK signaling might serve as a new therapeutic target of vascular remodeling in cardiovascular diseases.

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Article Details
DOI10.1161/01.cir.0000136025.96811.76
JournalCirculation
Year2004
AuthorsDaisuke Nagata, Ryo Takeda, Masataka Sata, Hiroshi Satonaka, Etsu Suzuki, Tetsuo Nagano, Yasunobu Hirata
LicenseOpen Access — see publisher for license terms
Citations196