CD36 and macrophages in atherosclerosis
S COLLOTTEIXEIRA, Julio Martín‐García, Chris McDermott‐Roe et al.
Research Article — Peer-Reviewed Source
Original research published by COLLOTTEIXEIRA et al. in Cardiovascular Research. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte/macrophage CD36 has been shown to play a critical role in the development of atherosclerotic lesions by its capacity to bind and endocytose oxidized low density lipoproteins (OxLDL), and it is implicated in the formation of foam cells. However, the significance of CD36 in atherosclerosis has recently been called into question by different studies, and therefore its exact role still needs to be clarified. The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis.
Full text is available at the publisher.
Read at Publisher| DOI | 10.1016/j.cardiores.2007.03.010 |
| Journal | Cardiovascular Research |
| Year | 2007 |
| Authors | S COLLOTTEIXEIRA, Julio Martín‐García, Chris McDermott‐Roe, Robin N. Poston, J MCGREGOR |
| License | Open Access — see publisher for license terms |
| Citations | 381 |