Neuroprotective Effect of EDR Peptide in Mouse Model of Huntington's Disease
Vladimir Khavinson, N. S. Linkova, E. O. Kukanova et al.
Research Article — Peer-Reviewed Source
Original research published by Khavinson et al. in Journal of Neurology and Neuroscience. Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder. The study in functioning and aging of neurons may give an opportunity to regulate these processes. Previous investigations demonstrated the ability of EDR peptide (Glu-Asp-Arg) to penetrate a cell nucleus and stimulate gene expression. The data obtained prompt EDR peptide capability to restore the morphology of spines in striatum neurons in Huntington’s disease (HD) mouse model. EDR peptide has been shown by us to bind the DNA in solution (absorption spectroscopy and dynamic light scattering) and in a computer model. The proposed model suggests that EDR peptide binds specific binding site oligo (dCG) along the DNA minor groove.
Full text is available at the publisher.
Read at Publisher| DOI | 10.21767/2171-6625.1000166 |
| Journal | Journal of Neurology and Neuroscience |
| Year | 2017 |
| Authors | Vladimir Khavinson, N. S. Linkova, E. O. Kukanova, Anastasiya Bolshakova, Anastasiya Gainullina, Solomon Tendler, E. A. Morozova, S. I. Tarnovskaya, Deby Susanti Pada Vinski, Vladimir Bakulev Nina Kasyanenko |
| License | Open Access — see publisher for license terms |
| Citations | 14 |