Role of BDNF in Neuroplasticity Associated with Alcohol Dependence
Danil Peregud, Valeria Yu. Baronets, Natalia N. Terebilina et al.
Research Article — Peer-Reviewed Source
Original research published by Peregud et al. in Biochemistry (Moscow). Redistributed under Open Access — see publisher for license terms. MedTech Research Group provides these references for informational purposes. We do not conduct original research. All studies are the work of their respective authors and institutions.
Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) is believed to be critically involved in this process. Here we aimed to review actual experimental and clinical data related to BDNF participation in neuroplasticity in the context of alcohol dependence. As has been shown in experiments with rodents, alcohol consumption is accompanied by the brain region-specific changes of BDNF expression and by structural and behavioral impairments. BDNF reverses aberrant neuroplasticity observed during alcohol intoxication. According to the clinical data parameters associated with BDNF demonstrate close correlation with neuroplastic changes accompanying alcohol dependence. In particular, the rs6265 polymorphism within the BDNF gene is associated with macrostructural changes in the brain, while peripheral BDNF concentration may be associated with anxiety, depression, and cognitive impairment. Thus, BDNF is involved in the mechanisms of alcohol-induced changes of neuroplasticity, and polymorphisms within the BDNF gene and peripheral BDNF concentration may serve as biomarkers, diagnostic or prognostic factors in treatment of alcohol abuse.
Full text is available at the publisher.
Read at Publisher| DOI | 10.1134/s0006297923030094 |
| Journal | Biochemistry (Moscow) |
| Year | 2023 |
| Authors | Danil Peregud, Valeria Yu. Baronets, Natalia N. Terebilina, N. V. Gulyaeva |
| License | Open Access — see publisher for license terms |
| Citations | 24 |